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  <xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xsd:import namespace="http://fasb.org/us-roles/2022" schemaLocation="https://xbrl.fasb.org/us-gaap/2022/elts/us-roles-2022.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/stpr/2022" schemaLocation="https://xbrl.sec.gov/stpr/2022/stpr-2022.xsd" />
  <xsd:import namespace="http://fasb.org/us-gaap/2022" schemaLocation="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd" />
  <xsd:import namespace="http://fasb.org/srt/2022" schemaLocation="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd" />
  <xsd:element name="PayablesToTissueSuppliersCurrent" id="azyo_PayablesToTissueSuppliersCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="RevenueInterestObligationCurrent" id="azyo_RevenueInterestObligationCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="RevenueInterestObligationNoncurrent" id="azyo_RevenueInterestObligationNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="InterestExpenseRecordedAsAdditionalRevenueInterestObligation" id="azyo_InterestExpenseRecordedAsAdditionalRevenueInterestObligation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="IncreaseDecreaseInObligationsToTissueSuppliers" id="azyo_IncreaseDecreaseInObligationsToTissueSuppliers" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="IncreaseDecreaseInContractWithCustomerLiabilityAndOtherLiabilities" id="azyo_IncreaseDecreaseInContractWithCustomerLiabilityAndOtherLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="PaymentsOnRevenueInterestObligation" id="azyo_PaymentsOnRevenueInterestObligation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfEstimatedUsefulLivesOfAssetsTableTextBlock" id="azyo_ScheduleOfEstimatedUsefulLivesOfAssetsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProcessingAndResearchEquipmentMember" id="azyo_ProcessingAndResearchEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueFromContractWithCustomerTermOfPayment" id="azyo_RevenueFromContractWithCustomerTermOfPayment" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueInterestObligationAbstract" id="azyo_RevenueInterestObligationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueInterestObligationTextBlock" id="azyo_RevenueInterestObligationTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ExercisePriceAsPercentageOfMarketValueOfShareOfCommonStock" id="azyo_ExercisePriceAsPercentageOfMarketValueOfShareOfCommonStock" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WhenCumulativeSalesOfProductsExceed100.0Member" id="azyo_WhenCumulativeSalesOfProductsExceed100.0Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WhenCumulativeSalesOfProductsExceed300.0Member" id="azyo_WhenCumulativeSalesOfProductsExceed300.0Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LigandPharmaceuticalsMember" id="azyo_LigandPharmaceuticalsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueInterestObligationPercentageOfFutureSales" id="azyo_RevenueInterestObligationPercentageOfFutureSales" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueInterestObligationPaymentsDueBasedOnCumulativeSales" id="azyo_RevenueInterestObligationPaymentsDueBasedOnCumulativeSales" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="RevenueInterestObligationCumulativeSales" id="azyo_RevenueInterestObligationCumulativeSales" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="RevenueInterestObligationAgreementTerm" id="azyo_RevenueInterestObligationAgreementTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueInterestObligationMember" id="azyo_RevenueInterestObligationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentVariableRateDivider" id="azyo_DebtInstrumentVariableRateDivider" type="xbrli:pureItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentExitFeePercent" id="azyo_DebtInstrumentExitFeePercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SurgalignHoldingsMember" id="azyo_SurgalignHoldingsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LicenseAgreementWithCookBiotechMember" id="azyo_LicenseAgreementWithCookBiotechMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PercentageOfRoyaltyOnSales" id="azyo_PercentageOfRoyaltyOnSales" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CardiovascularMember" id="azyo_CardiovascularMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PaymentOfLicenseFeePerYear" id="azyo_PaymentOfLicenseFeePerYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="RevenueInterestObligationAnnualMinimumSale" id="azyo_RevenueInterestObligationAnnualMinimumSale" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" id="azyo_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StockOptionPlan2020Member" id="azyo_StockOptionPlan2020Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LoanFacilityMandatoryPrepaymentPercentageCasualtyProceedsOfSecurity" id="azyo_LoanFacilityMandatoryPrepaymentPercentageCasualtyProceedsOfSecurity" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="LoanFacilityMandatoryPrepaymentCasualtyProceedsOfSecurityExcess" id="azyo_LoanFacilityMandatoryPrepaymentCasualtyProceedsOfSecurityExcess" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NumberOfClaimsRecallNoLawsuit" id="azyo_NumberOfClaimsRecallNoLawsuit" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="TimeBasedRsuMember" id="azyo_TimeBasedRsuMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PerformanceRestrictedStockUnitMember" id="azyo_PerformanceRestrictedStockUnitMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedCompensationAwardsAuthorizedTimeBased" id="azyo_ShareBasedCompensationAwardsAuthorizedTimeBased" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ShareBasedCompensationAwardsAuthorizedPerformanceBased" id="azyo_ShareBasedCompensationAwardsAuthorizedPerformanceBased" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementVestingRightsPercentageAtFirstYearAnniversary" id="azyo_ShareBasedCompensationArrangementVestingRightsPercentageAtFirstYearAnniversary" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ShareBasedCompensationPerformanceBasedSharePricePeriod" id="azyo_ShareBasedCompensationPerformanceBasedSharePricePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PerformanceBasedOptionsMember" id="azyo_PerformanceBasedOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TimeBasedOptionsMember" id="azyo_TimeBasedOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EmployeeStockPurchasePlanOfferingPeriod" id="azyo_EmployeeStockPurchasePlanOfferingPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ShareBasedCompensationNumberOfQuartersOfEqualVesting" id="azyo_ShareBasedCompensationNumberOfQuartersOfEqualVesting" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="SWKLoanFacilityMember" id="azyo_SWKLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NewAssetBasedRevolvingLoanFacilityMember" id="azyo_NewAssetBasedRevolvingLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentBasisSpreadOnVariableRateInKind" id="azyo_DebtInstrumentBasisSpreadOnVariableRateInKind" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="WarrantsIssuedDuringPeriod" id="azyo_WarrantsIssuedDuringPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="MaximumIssuableSharesForWarrantsAtClosingOfFinancing" id="azyo_MaximumIssuableSharesForWarrantsAtClosingOfFinancing" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="EarningsPerShareBasicAndDilutedOtherDisclosure1Abstract" id="azyo_EarningsPerShareBasicAndDilutedOtherDisclosure1Abstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MidcapLoanFacilityMember" id="azyo_MidcapLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MidcapCreditFacilityMember" id="azyo_MidcapCreditFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtQuarterlyPrincipalAmortizationAsPercentToFundedAmount" id="azyo_DebtQuarterlyPrincipalAmortizationAsPercentToFundedAmount" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="SwkLoanFacilityAndTermLoanFacilityMember" id="azyo_SwkLoanFacilityAndTermLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LoanAgreementCovenantThresholdAmountOfAssetSaleMandatoryPrepayment" id="azyo_LoanAgreementCovenantThresholdAmountOfAssetSaleMandatoryPrepayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="EmploymentAgreementInitialTerm" id="azyo_EmploymentAgreementInitialTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="IncreaseDecreaseContingentLiability" id="azyo_IncreaseDecreaseContingentLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DebtPrepaymentPenaltiesPriorToFirstAnniversary" id="azyo_DebtPrepaymentPenaltiesPriorToFirstAnniversary" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtPrepaymentPenaltiesAfterFirstAnniversary" id="azyo_DebtPrepaymentPenaltiesAfterFirstAnniversary" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ContingencyLitigationNumberSettledAndPaid" id="azyo_ContingencyLitigationNumberSettledAndPaid" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LossContingencyReceivableUnrecorded" id="azyo_LossContingencyReceivableUnrecorded" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeviceProtectionMember" id="azyo_DeviceProtectionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OrthobiologicsMember" id="azyo_OrthobiologicsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WomenSHealthMember" id="azyo_WomenSHealthMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ClassCommonStockWarrantsMember" id="azyo_ClassCommonStockWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NumberOfPlaintiffsInLawsuits" id="azyo_NumberOfPlaintiffsInLawsuits" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="FibercelLitigationProductLabilityMember" id="azyo_FibercelLitigationProductLabilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FibercelLitigationProductLabilityNegligenceBreachOfExpressAndImpliedWarrantiesAndPunitiveDamagesMember" id="azyo_FibercelLitigationProductLabilityNegligenceBreachOfExpressAndImpliedWarrantiesAndPunitiveDamagesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FibercelLossOfConsortiumMember" id="azyo_FibercelLossOfConsortiumMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FibercelStrictLiabilityClaimsForDefectiveDesignDefectiveManufactureAndFailureToWarnMember" id="azyo_FibercelStrictLiabilityClaimsForDefectiveDesignDefectiveManufactureAndFailureToWarnMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LegalSettlementPayments" id="azyo_LegalSettlementPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="GrossProfitBeforeIntangibleAssetAmortization" id="azyo_GrossProfitBeforeIntangibleAssetAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtAgreementCovenantPeriodAxis" id="azyo_DebtAgreementCovenantPeriodAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtAgreementCovenantPeriodDomain" id="azyo_DebtAgreementCovenantPeriodDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PeriodUntilAugust152023Member" id="azyo_PeriodUntilAugust152023Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PeriodAfterAugust152023Member" id="azyo_PeriodAfterAugust152023Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtCovenantMinimumLiquidity" id="azyo_DebtCovenantMinimumLiquidity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtCovenantNumberQuartersOperatingCashBurnMinimumLiquidity" id="azyo_DebtCovenantNumberQuartersOperatingCashBurnMinimumLiquidity" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentExitFeePercentagePlusAmount" id="azyo_DebtInstrumentExitFeePercentagePlusAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="NumberOfPatientsAffectedFromPostSurgicalMycobacteriumTuberculosisMtbInfectionsTreatedWithVbmProduct" id="azyo_NumberOfPatientsAffectedFromPostSurgicalMycobacteriumTuberculosisMtbInfectionsTreatedWithVbmProduct" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NumberOfLawsuitsFiledOrClaimsAsserted" id="azyo_NumberOfLawsuitsFiledOrClaimsAsserted" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LossesOnProductRecallAndMarketWithdrawal" id="azyo_LossesOnProductRecallAndMarketWithdrawal" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
</xsd:schema>
