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  <xsd:import namespace="http://www.xbrl.org/dtr/type/2020-01-21" schemaLocation="https://www.xbrl.org/dtr/type/2020-01-21/types.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xsd:import namespace="http://fasb.org/us-roles/2021-01-31" schemaLocation="https://xbrl.fasb.org/us-gaap/2021/elts/us-roles-2021-01-31.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/stpr/2021" schemaLocation="https://xbrl.sec.gov/stpr/2021/stpr-2021.xsd" />
  <xsd:import namespace="http://fasb.org/us-gaap/2021-01-31" schemaLocation="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd" />
  <xsd:import namespace="http://fasb.org/srt/2021-01-31" schemaLocation="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd" />
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  <xsd:element name="InterestExpenseRecordedAsAdditionalRevenueInterestObligation" id="azyo_InterestExpenseRecordedAsAdditionalRevenueInterestObligation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="IncreaseDecreaseInObligationsToTissueSuppliers" id="azyo_IncreaseDecreaseInObligationsToTissueSuppliers" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="IncreaseDecreaseInContractWithCustomerLiabilityAndOtherLiabilities" id="azyo_IncreaseDecreaseInContractWithCustomerLiabilityAndOtherLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="PaymentsOnRevenueInterestObligation" id="azyo_PaymentsOnRevenueInterestObligation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfEstimatedUsefulLivesOfAssetsTableTextBlock" id="azyo_ScheduleOfEstimatedUsefulLivesOfAssetsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProcessingAndResearchEquipmentMember" id="azyo_ProcessingAndResearchEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueFromContractWithCustomerTermOfPayment" id="azyo_RevenueFromContractWithCustomerTermOfPayment" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueInterestObligationAbstract" id="azyo_RevenueInterestObligationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
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  <xsd:element name="ExercisePriceAsPercentageOfMarketValueOfShareOfCommonStock" id="azyo_ExercisePriceAsPercentageOfMarketValueOfShareOfCommonStock" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WhenCumulativeSalesOfProductsExceed100.0Member" id="azyo_WhenCumulativeSalesOfProductsExceed100.0Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WhenCumulativeSalesOfProductsExceed300.0Member" id="azyo_WhenCumulativeSalesOfProductsExceed300.0Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LigandPharmaceuticalsMember" id="azyo_LigandPharmaceuticalsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueInterestObligationPercentageOfFutureSales" id="azyo_RevenueInterestObligationPercentageOfFutureSales" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueInterestObligationPaymentsDueBasedOnCumulativeSales" id="azyo_RevenueInterestObligationPaymentsDueBasedOnCumulativeSales" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="RevenueInterestObligationCumulativeSales" id="azyo_RevenueInterestObligationCumulativeSales" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="RevenueInterestObligationAgreementTerm" id="azyo_RevenueInterestObligationAgreementTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueInterestObligationMember" id="azyo_RevenueInterestObligationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="TermLoanFacilityMember" id="azyo_TermLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentVariableRateDivider" id="azyo_DebtInstrumentVariableRateDivider" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentExitFeePercent" id="azyo_DebtInstrumentExitFeePercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentPrepaymentPenaltyPercent" id="azyo_DebtInstrumentPrepaymentPenaltyPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="UnsecuredPromissoryNoteTwoMember" id="azyo_UnsecuredPromissoryNoteTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NoteToTissueSupplierMember" id="azyo_NoteToTissueSupplierMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SurgalignHoldingsMember" id="azyo_SurgalignHoldingsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MedtronicSofamorDanekUsaIncMember" id="azyo_MedtronicSofamorDanekUsaIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LicenseAgreementWithCookBiotechMember" id="azyo_LicenseAgreementWithCookBiotechMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfProductionFacilitiesUnderOperatingLease" id="azyo_NumberOfProductionFacilitiesUnderOperatingLease" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfAdministrativeAndResearchFacilityUnderOperatingLease" id="azyo_NumberOfAdministrativeAndResearchFacilityUnderOperatingLease" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PercentageOfRoyaltyOnSales" id="azyo_PercentageOfRoyaltyOnSales" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CoreProductsMember" id="azyo_CoreProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NonCoreProductsMember" id="azyo_NonCoreProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PaymentOfLicenseFeePerYear" id="azyo_PaymentOfLicenseFeePerYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ImpactOfCovid19PolicyTextBlock" id="azyo_ImpactOfCovid19PolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RevenueInterestObligationAnnualMinimumSale" id="azyo_RevenueInterestObligationAnnualMinimumSale" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" id="azyo_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StockOptionPlan2020Member" id="azyo_StockOptionPlan2020Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantedInPeriodFairValue" id="azyo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantedInPeriodFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="KeralinkInternationalMember" id="azyo_KeralinkInternationalMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StockholderSaleOfSharesThresholdAmountToReceiveAmount" id="azyo_StockholderSaleOfSharesThresholdAmountToReceiveAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="AmountDueFromStockholderUponSaleOfShares" id="azyo_AmountDueFromStockholderUponSaleOfShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="DueFromStockholderUponSaleOfSharesPeriod" id="azyo_DueFromStockholderUponSaleOfSharesPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LoanFacilityMandatoryPrepaymentPercentageCasualtyProceedsOfSecurity" id="azyo_LoanFacilityMandatoryPrepaymentPercentageCasualtyProceedsOfSecurity" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="LoanFacilityMandatoryPrepaymentCasualtyProceedsOfSecurityExcess" id="azyo_LoanFacilityMandatoryPrepaymentCasualtyProceedsOfSecurityExcess" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="AmountRemittedFromStockholderUponSaleOfShares" id="azyo_AmountRemittedFromStockholderUponSaleOfShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NumberOfClaimsRecallNoLawsuit" id="azyo_NumberOfClaimsRecallNoLawsuit" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="LossContingencyNewClaimsDismissedNumber" id="azyo_LossContingencyNewClaimsDismissedNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="LitigationProductLabilityMember" id="azyo_LitigationProductLabilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LossContingencyClaimsReFiledNumber" id="azyo_LossContingencyClaimsReFiledNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="LoanFacilityMandatoryPrepaymentPercentageProceedsOfAssetSale" id="azyo_LoanFacilityMandatoryPrepaymentPercentageProceedsOfAssetSale" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtInstrumentPrepaymentPenaltyPercentThroughJanuary212023" id="azyo_DebtInstrumentPrepaymentPenaltyPercentThroughJanuary212023" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtInstrumentPrepaymentPenaltyPercentAfterJanuary212023" id="azyo_DebtInstrumentPrepaymentPenaltyPercentAfterJanuary212023" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedInPeriodWeightedAverageGrantDateFairValue" id="azyo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedInPeriodWeightedAverageGrantDateFairValue" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ScenarioClosingPriceOfCommonStockExceeds10PerShareMember" id="azyo_ScenarioClosingPriceOfCommonStockExceeds10PerShareMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedPaymentArrangementSharePricePeriodForVesting" id="azyo_ShareBasedPaymentArrangementSharePricePeriodForVesting" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
</xsd:schema>
